Očkovanie proti čiernemu kašľu zrejme nepriaznivo ovplyvňuje imunitu dýchacích ciest. Štúdia preukázala, že očkované myši majú až 40-násobne vyššiu kolonizáciu baktériami B parapertussis oproti neočkovaným. Stále nie je plne objasnený mechanizmus vzniku prirodzenej odolnosti proti čiernemu kašľu, ale je už jasné, že je omnoho účinnejšia a trvácnejšia než protilátky z očkovania.
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