Podrobná prehľadová štúdia zhrnula dôkazy, že otrava ortuťou a autistické postihnutie má totožné biochemické prejavy. Aj iné okolnosti, ako napr. ďalšie ťažké kovy (olovo, kdmium) a infekcie dokážu vyvolať niektoré biochemické prejavy autizmu, alebo ich zhoršiť, ortuť však má výnimočné postavenie tým, že nielenže zhoršuje dopady ostatných okolností, ale sama osebe postačuje na vyvolanie zodpovedajúceho rozsahu poškodení.
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